CRISPR: On How it'll Change the Future

Authors

  • Alvina Aulia Bina Nusantara University
  • Rael Russel Hutapea Bina Nusantara University
  • Prawira Setya Abdima Bina Nusantara University
  • Akhmad Ali Emawan Bina Nusantara University
  • Ivan Sebastian Edbert Bina Nusantara University

DOI:

https://doi.org/10.21512/emacsjournal.v5i2.9975

Keywords:

CRISPR, Gene Editing, Genetic Disease

Abstract

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) explain genetic illness and how people can treat it using. CRISPR, a gene editing technology, has altered what is now possible in animal modification and the development of human treatments. Technological advancements enable new enhanced plants, breakthrough concepts for human medicine, and appealing yet feasible techniques for reducing vector-borne illnesses. CRISPR is used as a diagnostic method for several critical diseases like cancer. CRISPR can detect and identify the DNA and RNA to identify the cause of the pathogen, like viruses or bacteria with high sensitivity. In this research, the researcher will explain how CRISPR will change the future, specifically for medical purposes. The researcher will do the Systematic Literature Review (SLR) to describe CRISPR. The goal considering CRISPR in the future is routinely used to edit the genetics of plant, bacterial, and even animal models for good purposes. It also nourishes and protects the human body from diseases by examining target genes in genome modification, investigating, and treating genetic disorders, infectious diseases, and immunological diseases. In CRISPR applications for hereditary illnesses, the CRISPR/Cas technology has been used for gene therapy to protect humans against sickness. Although the limitation of the technology is that still in the initial stages, CRISPR could be one of the groundbreaking methods in the future.

Dimensions

Plum Analytics

Author Biographies

Alvina Aulia, Bina Nusantara University

Computer Science Department, BINUS Graduate Program - Doctor of Computer Science

Rael Russel Hutapea, Bina Nusantara University

Computer Science Department, School of Computer Science

Prawira Setya Abdima, Bina Nusantara University

Computer Science Department, School of Computer Science

Akhmad Ali Emawan, Bina Nusantara University

Computer Science Department, School of Computer Science

Ivan Sebastian Edbert, Bina Nusantara University

Computer Science Department, School of Computer Science

References

Bridget Balch. (2021). "The future of CRISPR is now", in AAMC/Health Care, https://www.aamc.org/news-insights/future-crispr-now.

Chen, B., Zou, W., Xu, H., Liang, Y., & Huang, B. (2018). Efficient labeling and imaging of protein-coding genes in living cells using CRISPR-Tag. Nature communications, 9(1), 5065.

Davies, K. (2020). Editing humanity: The CRISPR revolution and the new era of genome editing. Simon and Schuster. Pegasus: 9781643133089.

Edraki, A., Mir, A., Ibraheim, R., Gainetdinov, I., Yoon, Y., Song, C. Q., ... & Sontheimer, E. J. (2019). A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing. Molecular cell, 73(4), 714-726.

Emily Mullin. (2020). "The 7 Craziest Ways CRISPR Is Being Used Right Now",in Medium / OneZero, https://onezero.medium.com/the-7- craziest-ways-crispr-is-being-used-right-now-bcf3bd203f23.

Ferdosi, S. R., Ewaisha, R., Moghadam, F., Krishna, S., Park, J. G., Ebrahimkhani, M. R., ... & Anderson, K. S. (2019). Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Nature communications, 10(1), 1842.

Gonzalez-Avila, L. U., Vega-López, J. M., Pelcastre-Rodríguez, L. I., Cabrero-Martínez, O. A., Hernández-Cortez, C., & Castro-Escarpulli, G. (2021). The Challenge of CRISPR-Cas toward bioethics. Frontiers in Microbiology, 12, 657981.

Greely, H. T. (2022). CRISPR people: The science and ethics of editing humans. MIT Press.

Greg Licholai. (2018). "Is CRISPR Worth the Risk?", Management in Practice, in Yale Insights. https://insights.som.yale.edu/insights/is-crispr-worth-the-risk.

Kennedy, E. M., & Cullen, B. R. (2017). Gene editing: a new tool for viral disease. Annual review of medicine, 68, 401-411.

Khan, S., Mahmood, M. S., Zafar, H., Habibullah, S., & Ahmad, A. (2018). CRISPR/Cas9: the Jedi against the dark empire of diseases. Journal of biomedical science, 25(1), 1-18. | Full Text (biomedcentral.com).

Kirshner, H. S. (2022). The Code Breaker, Jennifer Doudna, Gene Editing, and the Future of the Human Race.

Ledford, H. (2020). CRISPR gene editing in human embryos wreaks chromosomal mayhem. Nature, 583(7814), 17-18. https://www.nature.com/articles/d41586-020-01906-4.

Meenakshi Prabhune, PH.D. (2021). “Diseases CRISPR Could Cure: Latest Updates On Research Studies And Human Trials”, in TheBench, https://www.synthego.com/blog/crispr-cure-diseases#using-crispr-for-cancer-treatment.

Meiliana, A., Dewi, N. M., & Wijaya, A. (2017). Genome Editing with Crispr-Cas9 Systems: Basic Research and Clinical Applications. The Indonesian Biomedical Journal, 9(1), 1-16.

Michael W. Richardson. (2019). "What Is CRISPR Currently Being Used For?",in BrainFacts/SfN/, https://neuronline.sfn.org/sitecore/content/Home/BrainFacts2/In-the-Lab/Tools-and-Techniques/2019/CRISPR-Explained-071519

National Geographic, Mutation, accessed 11 April 2022, https://www.nationalgeographic.org/encyclopedia/mutation/.

National Institute of General Medical Sciences (NIGMS), Genes, accessed 11 April 2022, https://nigms.nih.gov/education/genes

National Library of Medicine, How can gene variants affect health and development?, accessed 11 April 2022, https://medlineplus.gov/genetics/understanding/mutationsanddisorders/mutationscausedisease/.

Oakes, B. L., Fellmann, C., Rishi, H., Taylor, K. L., Ren, S. M., Nadler, D. C., ... & Savage, D. F. (2019). CRISPR-Cas9 circular permutants as programmable scaffolds for genome modification. Cell, 176(1-2), 254-267.

Papasavva, P., Kleanthous, M., & Lederer, C. W. (2019). Rare opportunities: CRISPR/Cas-based therapy development for rare genetic diseases. Molecular diagnosis & therapy, 23(2), 201-222.

Plumer, B., Barclay, E., Belluz, J., & Irfan, U. (2018). A simple guide to CRISPR, one of the biggest science stories of the decade. VOX Media.

Rodríguez-Rodríguez, D. R., Ramírez-Solís, R., Garza-Elizondo, M. A., Garza-Rodríguez, M. D. L., & Barrera-Saldaña, H. A. (2019). Genome editing: A perspective on the application of CRISPR/Cas9 to study human diseases. International journal of molecular medicine, 43(4), 1559-1574.

S. Robert, FDA approves first test of CRISPR to correct genetic defect causing sickle cell disease. UC Berkeley media relations. 2021.

Sand, M., Bredenoord, A. L., & Jongsma, K. R. (2019). After the fact—the case of CRISPR babies. European Journal of Human Genetics, 27(11), 1621-1624.

Singh, V., & Dhar, P. K. (Eds.). (2020). Genome engineering via CRISPR-Cas9 system. Academic Press.

Tiruneh G/Medhin, M., Chekol Abebe, E., Sisay, T., Berhane, N., Bekele, T., & Asmamaw Dejenie, T. (2021). Current applications and future perspectives of CRISPR-Cas9 for the treatment of lung cancer. Biologics: Targets and Therapy, 199-204.

Uddin, F., Rudin, C. M., & Sen, T. (2020). CRISPR gene therapy: applications, limitations, and implications for the future. Frontiers in oncology, 10, 1387.

Wu, X., Mao, S., Ying, Y., Krueger, C. J., & Chen, A. K. (2019). Progress and challenges for live-cell imaging of genomic loci using CRISPR-based platforms. Genomics, proteomics & bioinformatics, 17(2), 119-128.

Xie, N., Zhou, Y., Sun, Q., & Tang, B. (2018). Novel epigenetic techniques provided by the CRISPR/Cas9 system. Stem cells international, 2018.

Yuan, J., Ma, Y., Huang, T., Chen, Y., Peng, Y., Li, B., ... & Chang, X. (2018). Genetic modulation of RNA splicing with a CRISPR-guided cytidine deaminase. Molecular cell, 72(2), 380-394.

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Published

2023-05-31

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