Leveraging Artificial Intelligence (AI) Methods for Non-Small Cell Lung Cancer (NSCLC) Detection: A Review

Authors

  • Faisal Asadi Jambi University
  • Ashraf Alif Adillah Bina Nusantara University
  • Jonathan Lucas Fontana Bina Nusantara University
  • Michael Dimas Chrispradipta Bina Nusantara University
  • Mousa Khalil Mousa Ayesh Bina Nusantara University
  • Wairanatha Halim Bina Nusantara University

Keywords:

artificial intelligence, cancer detection, non-small cell lung cancer, NSCLC

Abstract

One of the main causes of cancer-death that significant to global public health concern is lung cancer. NSCLC has been categorized as a burden disease, with an estimated reaching 85% of all lung cancer cases around the world. The problem was that NSCLC disease could only be detected when the disease has grown at a late stage. Therefore, AI technology is also being implemented to handle NSCLC disease. This review discusses how AI has played a role in treating NSCLC disease in the last five years of research journals that collected 5 years between 2019-2024. The database resources are from PubMed, Scopus, and Google Scholar. The process of selecting journal papers was analyzed based on an in-depth understanding of NSCLC disease journals as considered an inclusion criterion. This review used the PRISMA to analysis and review 17 journals. After carrying out the analysis process on the AI-NSCLC journals, we found that AI has been able to help humans respond to cases of NSCLC patients, starting from the detection stage, comprehensive diagnosis, and providing treatment recommendations. Treatments of NSCLC tend to be more personalized and could run more effectively and efficiently based on medical images input into the AI model. However, considering the urgency and vulnerability of the application of these AI models, which will be directly related to human health, the medical images dataset is also quite limited and the biggest challenge for AI-NSCLC.

Dimensions

Author Biographies

Faisal Asadi, Jambi University

Department of Electrical Engineering, Faculty of Science and Technology

Ashraf Alif Adillah, Bina Nusantara University

Computer Science Department, School of Computer Science

Jonathan Lucas Fontana, Bina Nusantara University

Computer Science Department, School of Computer Science

Michael Dimas Chrispradipta, Bina Nusantara University

Computer Science Department, School of Computer Science

Mousa Khalil Mousa Ayesh, Bina Nusantara University

Computer Science Department, School of Computer Science

Wairanatha Halim, Bina Nusantara University

Computer Science Department, School of Computer Science

References

Ahmed, S., Raza, B., Hussain, L., Aldweesh, A., Omar, A., Khan, M. S., Eldin, E. T., & Nadim, M. A. (2023). The deep learning ResNet101 and ensemble XGBoost algorithm with hyperparameters optimization accurately predict the lung cancer. Applied Artificial Intelligence, 37(1). https://doi.org/10.1080/08839514.2023.2166222

Asadi, F., Salehnasab, C., & Ajori, L. (2020). Supervised algorithms of machine learning for the prediction of cervical cancer. Journal of Biomedical Physics and Engineering, 10(4), 513–522. https://doi.org/10.31661/jbpe.v0i0.1912-1027

Çalışkan, M., & Tazaki, K. (2023). AI/ML advances in non-small cell lung cancer biomarker discovery. Frontiers in Oncology, 13, 1–16. https://doi.org/10.3389/fonc.2023.1260374

Cellina, M., Cacioppa, L. M., Cè, M., Chiarpenello, V., Costa, M., Vincenzo, Z., Pais, D., Bausano, M. V., Rossini, N., Bruno, A., & Floridi, C. (2023). Artificial intelligence in lung cancer screening: The future is now. Cancers, 15(17). https://doi.org/10.3390/cancers15174344

Charan, N., & Parthiban, S. (2023). Decision tree over KNN for lung cancer detection to increase accuracy. Journal of Survey in Fisheries Sciences, 10(1S).

Chen, H., Xiong, W., Wu, J., Zhuang, Q., & Yu, G. (2020). Decision-making model based on ensemble method in auxiliary medical system for non-small cell lung cancer. IEEE Access, 8, 171903–171911. https://doi.org/10.1109/ACCESS.2020.3024840

Chiang, Y. T., Seow, K. M., & Chen, K. H. (2024). The pathophysiological, genetic, and hormonal changes in preeclampsia: A systematic review of the molecular mechanisms. International Journal of Molecular Sciences, 25(8). https://doi.org/10.3390/ijms25084532

Chiu, H. Y., Chao, H. S., & Chen, Y. M. (2022). Application of artificial intelligence in lung cancer. Cancers, 14(6). https://doi.org/10.3390/cancers14061370

Chowdary, G. J., G, S., M, P., & Yogarajah, P. (2023). Nucleus segmentation and classification using residual SE-UNet and feature concatenation approach in cervical cytopathology cell images. Technology in Cancer Research and Treatment, 22. https://doi.org/10.1177/15330338221134833

Fiste, O., Gkiozos, I., Charpidou, A., & Syrigos, N. K. (2024). Artificial intelligence-based treatment decisions: A new era for NSCLC. Cancers, 16(4). https://doi.org/10.3390/cancers16040831

Grossman, R., Haim, O., Abramov, S., Shofty, B., & Artzi, M. (2021). Differentiating small-cell lung cancer from non-small-cell lung cancer brain metastases based on MRI using EfficientNet and transfer learning approach. Technology in Cancer Research and Treatment, 20, 1–7. https://doi.org/10.1177/15330338211004919

Hou, X., Shen, G., Zhou, L., Li, Y., Wang, T., & Ma, X. (2022). Artificial intelligence in cervical cancer screening and diagnosis. Frontiers in Oncology, 12, 1–13. https://doi.org/10.3389/fonc.2022.851367

Karasu Benyes, Y., Welch, E. C., Singhal, A., Ou, J., & Tripathi, A. (2022). A comparative analysis of deep learning models for automated cross-preparation diagnosis of multi-cell liquid Pap smear images. Diagnostics, 12(8). https://doi.org/10.3390/diagnostics12081838

Khamparia, A., Gupta, D., Rodrigues, J. J. P. C., & de Albuquerque, V. H. C. (2021). DCAVN: Cervical cancer prediction and classification using deep convolutional and variational autoencoder network. Multimedia Tools and Applications, 80(20), 30399–30415. https://doi.org/10.1007/s11042-020-09607-w

Kim, G., Park, Y. M., Yoon, H. J., & Choi, J. H. (2023). Multi-kernel and multi-scale learning based deep ensemble model for predicting recurrence of non-small cell lung cancer. PeerJ Computer Science, 9, 1–20. https://doi.org/10.7717/peerj-cs.1311

Kriegsmann, M., Haag, C., Weis, C. A., Steinbuss, G., Warth, A., Zgorzelski, C., Muley, T., Winter, H., Eichhorn, M. E., Eichhorn, F., Kriegsmann, J., Christopolous, P., Thomas, M., Witzens-Harig, M., Sinn, P., von Winterfeld, M., Heussel, C. P., Herth, F. J. F., Klauschen, F., … Kriegsmann, K. (2020). Deep learning for the classification of small-cell and non-small-cell lung cancer. Cancers, 12(6), 1–15. https://doi.org/10.3390/cancers12061604

Lipkova, J., Chen, R. J., Chen, B., Lu, M. Y., Barbieri, M., Shao, D., Vaidya, A. J., Chen, C., Zhuang, L., Williamson, D. F. K., Shaban, M., Chen, T. Y., & Mahmood, F. (2022). Artificial intelligence for multimodal data integration in oncology. Cancer Cell, 40(10), 1095–1110. https://doi.org/10.1016/j.ccell.2022.09.012

Mayer, C., Ofek, E., Fridrich, D. E., Molchanov, Y., Yacobi, R., Gazy, I., Hayun, I., Zalach, J., Paz-Yaacov, N., & Barshack, I. (2022). Direct identification of ALK and ROS1 fusions in non-small cell lung cancer from hematoxylin and eosin-stained slides using deep learning algorithms. Modern Pathology, 35(12), 1882–1887. https://doi.org/10.1038/s41379-022-01141-4

Mulmule, P. V., & Kanphade, R. D. (2022). Classification of cervical cytology overlapping cell images with transfer learning architectures. Biomedical and Pharmacology Journal, 15(1), 277–284. https://doi.org/10.13005/bpj/2364

Özbay, E., & Özbay, F. A. (2023). Interpretable Pap smear image retrieval for cervical cancer detection with rotation invariance mask generation deep hashing. Computers in Biology and Medicine, 154. https://doi.org/10.1016/j.compbiomed.2023.106574

Quanyang, W., Yao, H., Sicong, W., Linlin, Q., Zewei, Z., Donghui, H., Hongjia, L., & Shijun, Z. (2024). Artificial intelligence in lung cancer screening: Detection, classification, prediction, and prognosis. Cancer Medicine, 13(7), 1–19. https://doi.org/10.1002/cam4.7140

Sachan, P., Singh, M., Patel, M., & Sachan, R. (2018). A study on cervical cancer screening using Pap smear test and clinical correlation. Asia-Pacific Journal of Oncology Nursing, 5(3), 337–341. https://doi.org/10.4103/apjon.apjon_15_18

Shao, D., Dai, Y., Li, N., Cao, X., Zhao, W., Cheng, L., Rong, Z., Huang, L., Wang, Y., & Zhao, J. (2022). Artificial intelligence in clinical research of cancers. Briefings in Bioinformatics, 23(1), 1–12. https://doi.org/10.1093/bib/bbab523

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660

Suphalakshmi, A., Ahilan, A., Jeyam, A., & Subramanian, M. (2022). Cervical cancer classification using EfficientNet and fuzzy extreme learning machine. Journal of Intelligent and Fuzzy Systems, 43(5), 6333–6342. https://doi.org/10.3233/JIFS-220296

Tashtoush, Y., Obeidat, R., Al-Shorman, A., Darwish, O., Al-Ramahi, M., & Darweesh, D. (2023). Enhanced convolutional neural network for non-small cell lung cancer classification. International Journal of Electrical and Computer Engineering, 13(1), 1024–1038. https://doi.org/10.11591/ijece.v13i1.pp1024-1038

Uzun, A., Laliberte, A., Parker, J., Andrew, C., Winterrowd, E., Sharma, S., Istrail, S., & Padbury, J. F. (2012). DbPTB: A database for preterm birth. Database, 2012, 1–10. https://doi.org/10.1093/database/bar069

Walter, W., Pohlkamp, C., Meggendorfer, M., Nadarajah, N., Kern, W., Haferlach, C., & Haferlach, T. (2023). Artificial intelligence in hematological diagnostics: Game changer or gadget? Blood Reviews, 58, 101019. https://doi.org/10.1016/j.blre.2022.101019

Wang, C., Ma, J., Shao, J., Zhang, S., Liu, Z., Yu, Y., & Li, W. (2022). Predicting EGFR and PD-L1 status in NSCLC patients using multitask AI system based on CT images. Frontiers in Immunology, 13, 1–12. https://doi.org/10.3389/fimmu.2022.813072

Wang, X., Chen, P., Ding, G., Xing, Y., Tang, R., Peng, C., Ye, Y., & Fu, Q. (2021). Dual-scale categorization based deep learning to evaluate programmed cell death ligand 1 expression in non-small cell lung cancer. Medicine, 100(20), e25994. https://doi.org/10.1097/MD.0000000000025994

Wu, J., Liu, C., Liu, X., Sun, W., Li, L., Gao, N., Zhang, Y., Yang, X., Zhang, J., Wang, H., Liu, X., Huang, X., Zhang, Y., Cheng, R., Chi, K., Mao, L., Zhou, L., Lin, D., & Ling, S. (2022). Artificial intelligence-assisted system for precision diagnosis of PD-L1 expression in non-small cell lung cancer. Modern Pathology, 35(3), 403–411. https://doi.org/10.1038/s41379-021-00904-9

Yang, Z., Zhou, D., & Huang, J. (2023). Identifying explainable machine learning models and a novel SFRP2+ fibroblast signature as predictors for precision medicine in ovarian cancer. International Journal of Molecular Sciences, 24(23). https://doi.org/10.3390/ijms242316942

Ye, M., Tong, L., Zheng, X., Wang, H., Zhou, H., Zhu, X., Zhou, C., Zhao, P., Wang, Y., Wang, Q., Bai, L., Cai, Z., Kong, F. M., Wang, Y., Li, Y., Feng, M., Ye, X., Yang, D., Liu, Z., … Bai, C. (2022). A classifier for improving early lung cancer diagnosis incorporating artificial intelligence and liquid biopsy. Frontiers in Oncology, 12, 1–10. https://doi.org/10.3389/fonc.2022.853801

Zafar, M. A., Ziganshin, B. A., Li, Y., Ostberg, N. P., Rizzo, J. A., Tranquilli, M., Mukherjee, S. K., & Elefteriades, J. A. (2023). "Big data" analyses underlie clinical discoveries at the aortic institute. Yale Journal of Biology and Medicine, 96(3), 427–440. https://doi.org/10.59249/LNDZ2964

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Published

2026-05-29

How to Cite

Asadi, F., Adillah, A. A., Fontana, J. L., Chrispradipta, M. D., Ayesh, M. K. M., & Halim, W. (2026). Leveraging Artificial Intelligence (AI) Methods for Non-Small Cell Lung Cancer (NSCLC) Detection: A Review. Engineering, MAthematics and Computer Science Journal (EMACS), 8(1), 113–120. Retrieved from https://journal.binus.ac.id/index.php/EMACS/article/view/15454
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